Project E2:   Expert Panel on Neuroprotectant Treatment of Mild Brain Injury

Principal Investigator:  Joseph Bleiberg, PhD

Funding Source: Neuroscience Research Center (USAMRMC)

Abstract:
In the late 1970s and 1980s there was a rush of clinical trials using neuroprotectants as treatment for traumatic brain injury.  Unfortunately, the initial excitement and optimism gave way to disappointment in the face of poor results, with several agents actually appearing to exacerbate the injury they were designed to treat.  The present project will assemble a multidisciplinary group of experts to review newer generation neuroprotectants and determine whether there is a sound scientific rationale to reconsider a neuroprotectant clinical trial.  Specifically, the panel will review candidate neuroprotectants in order to produce one of two actions: 1) a state-of-the-art literature review of neuroprotectants, with the conclusion that none are promising for current clinical trials, or, 2) the identification of one or more promising neuroprotectants, with the conclusion that a clinical trial should be undertaken.  In the event of the latter conclusion, the literature review will serve as the introduction for a clinical trial research proposal.

Progress and Outcomes:
This project has been deferred into Year 3 (2005)